Chicken IL-16 ELISA Kit

Interleukin 16 (IL-16) is a pleiotropic cytokine that has been characterized as a chemoattractant for certain immune cells expressing the cell surface molecule CD4, and has effects on mixed lymphocyte reaction and inhibition of HIV viral replication. Because this cytokine was discovered in 1982 for its T lymphocyte chemotactic activity, it was named “Lymphocyte Chemoattractant Factor (LCF)” until it was designated interleukin-16 in 1995. The product of this gene is generated as a precursor molecule, pro-IL-16, which is then processed to yield two functional proteins. IL-16 forms homotetramers and this structure is required for its bioactivity. The cytokine function is exclusively attributed to the secreted C-terminal peptide, while the N-terminal product may play a role in cell cycle control. Caspase 3 is reported to be involved in the proteolytic processing of this protein. IL-16 is released by a variety of immune (T cells, esinophils, and dendritic cells) and non-immune (fibroblasts, epithelial, and neurona) cells (Center et al., 1997; Cruikshank et al., 2000). In the non-diseased state, IL-16 mRNA is almost exclusively expressed on lymphatic tissue, and high levels in T cells. During inflammation, IL-16 is synthesized in a number of other tissues (Smith and Humphries, 2009). The sequence, structure, and function of IL-16 are highly conserved in all species examined. Thus far, all species of IL-16 tested induce similar bioactivities on CD4+ T cells. Chicken IL-6 has been cloned by Min et al. (2004) and shows 86% sequence identity to duct pro-IL-16, and 49-52% to various mammalian homologues. The recombinant chicken IL-16 showed chemoattractive activity to splenic lymphocytes.

Chicken IL-16 ELISA Kit  E33-800

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